August 7, 2025 at 9:33 am

When Prescriptions Collide: A Fatal Reality of Polypharmacy

A newly published forensic investigation reveals how a tragic suicide was caused by the interaction of three commonly prescribed psychiatric drugs. This case, published in the International Journal of Legal Medicine, highlights how even drugs considered “safe” can become lethal in combination. The synergistic effects of these medications triggered serotonin toxicity, respiratory depression, and ultimately medication-induced suicide.

The danger wasn’t just the overdose—it was how the drugs amplified each other’s toxic effects, overwhelming the central nervous system. The case shows how akathisia, serotonin toxicity, and other adverse drug effects are often overlooked. Theres is an urgent need for better therapeutic monitoring, clear communication about risks, and education for prescribers, patients, and caregivers. Read the full study at: https://bioengineer.org/paroxetine-overdose-suicide-linked-to-benzodiazepine-antipsychotics/.